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Cocaine is a sympathomimetic drug that has central nervous system stimulant and euphoric properties. High doses of cocaine can lead to panic attacks, schizophrenic signs, seizures, hyperthermia and arterial hypertension, arrhythmias, stroke, aortic dissections, intestinal ischemia, myocardial injury, and anxiety. Supportive therapy is used to manage toxicities, such as intravenous benzodiazepines for seizures, agitation, and hypertension and cooling techniques for hyperthermia. Withdrawal manifests as depression, difficulty with concentration, and drowsiness.how to buy cocaine The majority of cocaine users are occasional, or even mildly addicted to the drug. Only 25% to 25% of adults who are addicted to cocaine have met the criteria for abuse and dependence. The prevalence among adolescents has recently declined. The availability and abuse of highly psychoactive forms like cocaine has made it more difficult for people to get addicted. U.S. drug abuse is characterized by a high level of purity, with cocaine containing approximately 45-60%. However, there are many fillers, weighting agent and contaminants.The majority of cocaine consumed in the United States is inhaled and vaporized. However, it can also be inhaled by mouth or intravenously. The powdered hydrochloride, which is used for inhalation, is usually converted to a less volatile form by adding sodium bicarbonate or water, as well as heating. The precipitate (cocaine), is then evaporated using heating (it does NOT burn) and inhaled. The onset of effect is rapid, and the intensity is the same as that of high potency cocaine rivals when injected by injection. Tolerance to cocaine is observed, and withdrawal after intense use is characterized by drowsiness, difficulty concentrating, increased appetite, and depression. There is an intense urge to use the drug again after a time of withdrawal.PathophysiologyCocaine, an alkaloid found in the leaves and flowers of the coca plant increases serotonin, dopamine and norepinephrine activity in the central nervous system and peripheral nervous system.Dopamine activity increases, leading to drug abuse and dependence.Noradrenaline activation causes sympathomimetic symptoms: tachycardia.Cocaine also blocks sodium channels, due to which its local anesthetic effect is manifested. The effects of cocaine on the blood vessels can cause vasoconstriction, which can then affect any other organ. Other possible complications include myocardial and cerebral infarctions, cerebral ischemias and hemorhages, Aortic Dissection, intestinal and renal ischemia.The way in which cocaine is administered will determine the moment when the effects begin.Smoking and intravenous injections: immediate onset, peak effects 3-5 min later, duration 15-20 minutesTransdermal administration: Effects begin within 3-5 minutes, peak after 20-30 minutes. Duration is approximately 45-90 minutes.Oral administration: Effects begin after 10 minutes. Maximum effects occur after 60 minutes. Duration of the effects is approximately 90 minutes.Cocaine is a short-acting drug. Hardcore addicts can inject it intravenously or smoke it repeatedly every 10 to15 minutes.PregnancyCocaine use during pregnancy can affect the fetus; there is an increased incidence of placental detachment and spontaneous abortion.Clinical manifestationshttps://www.kharkhorincourt.gov.mn/user/bulbsummer61/ Acute effectsDependent on the method of consumption, the effects of cocaine may differ. Cocaine can be administered intravenously, or smoked. This causes hyperstimulation. The excitement and high states are similar to those obtained by injecting amphetamines. For addicts who inhale cocaine powder by the nose, these feelings are less intense.Addicts who smoke the drug may develop pneumothorax or pneumomediastinum, causing chest pain, shortness of breath, or both. Cocaine use can also cause chest pain ("cocaine-chest pain"), although myocardial injury from cocaine use may not be present. The mechanism behind this chest pain is still unknown. There have been reports of arrhythmias, conduction abnormalities and other symptoms. Sudden death can result from cardiac effects. "Marathon" (continuous usage), which can last for several days, can cause exhaustion syndrome.Overdose and toxicityOverdose causes severe anxiety, panic, agitation, aggressiveness, insomnia, hallucinations, paranoid delusions, impaired judgment, tremors, seizures, and delirium. Mydriasis and sweating are observed, and heart rate and blood pressure increase. Death may occur as a result of myocardial infarction or arrhythmia.